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The Plutonians unsuccessfully try to clone Master Shake, instead creating “Major Shake,” an abomination with a boombox protruding from his abdomen and feminine shoes on his feet. Major Shake is sent to earth as part of the Plutonians’ plan to “de-terraform” Earth.

Frylock buys Meatwad a new doll named “Happy Time Harry”. It turns out that the doll is a depressed, cynical, suicidal, knife-wielding, drug-addicted alcoholic who makes Meatwad as depressed and cynical as he is.

MC Pee Pants, a rap star whom Meatwad idolizes, turns out to be an anthropomorphic spider who puts subliminal messages in his songs as part of a convoluted scheme to unleash demons from Hell to run a massive diet pill pyramid scheme.

The Mooninites trick Meatwad into helping them acquire the Foreigner Belt, a magical belt that gives the bearer the powers of the band Foreigner.

A well-mannered benevolent entity made of mold inhabits the household and befriends Meatwad. Shake becomes jealous, as everyone likes “Ol’ Drippy” more than him.