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Carl’s new male enhancement device produces some unsavory side effects, including radioactive human waste. Ground contamination leads the whole of Meatwad’s deceased pets to come back for some sexually transmitted zombification laced revenge.

The Aqua Teens must either escape the spider cocoons their landlord Marcula has trapped them in, or pay the rent they owe him. Meanwhile Carl gets yet another new neighbor, a huge demon named Paul who is going through a difficult custody battle.

A trio of Sirens (Chrysanthemum, The BJ Queen, and John Kruk) move into the Aqua Teens’ house and catch Carl’s interest. Guest appearances from Neko Case, Kelly Hogan, and former professional baseball star John Kruk.

When the Aqua Teens are cocooned in the desert by their landlord Marcula, Carl tries to sell their house to robots.